Express Scripts Headquarters Address, Corporate Office Location, and Contact Details

 

About

Express Scripts is one of the largest pharmacy benefit managers (PBMs) in the United States and a wholly owned subsidiary of The Cigna Group (NYSE: CI). Founded in 1986 and headquartered at 1 Express Way in St. Louis, Missouri, Express Scripts was acquired by Cigna in December 2018 for approximately $67 billion and now operates as a core component of Cigna’s Evernorth Health Services segment. The company manages prescription drug plans for health insurers, employers, labor unions, and government health plans — processing more than 1.4 billion prescriptions annually and serving over 123.6 million pharmacy customers as of year-end 2025.

Quick Facts (max 8)

Founded

1986

HQ

1 Express Way, St. Louis, MO 63121

Industry

Pharmacy Benefit Management / Healthcare

Parent Company

The Cigna Group (NYSE: CI) — acquired December 2018

Parent Division

Evernorth Health Services

Cigna CEO

David Cordani (President & CEO, The Cigna Group)

Pharmacy Customers (2025)

123.6 million

Annual Prescriptions Processed

1.4 billion+

What Brings You Here? Find the Right Contact

Prescription / order / refund

Call 1-800-282-2881 (24/7) or log in at express-scripts.com. A patient care advocate or pharmacist is available around the clock for refills, order status, pricing, and billing disputes.

Medicare members

Call 1-866-529-4917 (TTY: 1-800-899-2114), available 24/7 for Medicare Part D and Medicare Advantage pharmacy support.

TRICARE members

Express Scripts administers the TRICARE Pharmacy Program. TRICARE-specific support is handled through a dedicated line listed at express-scripts.com/contact-us under the TRICARE section.

Technical support / online account

Call 1-800-711-5672 for issues with your online account, mobile app, login access, and digital enrollment.

Prior authorization / appeal

For prescription denials, call 1-800-282-2881 and ask to initiate a coverage review or formulary exception request. Urgent prior authorization reviews must be completed within 24 hours under federal PBM standards.

Employer / plan sponsor

For new plan or PBM contract inquiries, route through Cigna’s enterprise channels at cigna.com/evernorth or write to 1 Express Way, St. Louis, MO 63121.

Media / press

Media inquiries for Express Scripts are handled through The Cigna Group’s communications team at newsroom.cigna.com.

Legal / subpoena

Serve Express Scripts, Inc., 1 Express Way, St. Louis, MO 63121. For parent-level matters, serve The Cigna Group, 900 Cottage Grove Road, Bloomfield, CT 06002.

Phone Directory

Patient Customer Service (24/7)

1-800-282-2881 — Prescriptions, refills, billing, order status, and general member support. Available every day of the year

TTY (Hearing Impaired)

1-800-759-1089 — 24/7 TTY access on the main patient service line

Medicare Member Line (24/7)

1-866-529-4917 — Dedicated Medicare Part D and Medicare Advantage pharmacy support

Medicare TTY

1-800-899-2114

Technical Support / Online Account

1-800-711-5672 — App, login, and digital account assistance

Alternate Customer Service

1-800-206-4005 — Alternative line listed in public consumer directories

Corporate HQ (St. Louis)

(314) 996-0900 — Main campus switchboard for business-level inquiries

Corporate Headquarters Address

Express Scripts, Inc.

1 Express Way
St. Louis, MO 63121
United States

Parent Company

The Cigna Group
900 Cottage Grove Road
Bloomfield, CT 06002
United States

How to Escalate a Complaint

1. Call 1-800-282-2881 first. Available 24/7. Ask for a supervisor immediately if the first agent cannot resolve the issue. Get a case number on every call and note the representative’s name.
2. Request a formal appeal or coverage review. For prescription denials or prior authorization refusals, you have the right to formally appeal under federal law. Ask the rep to initiate the appeal on the first call — outcomes must be delivered in writing within federally mandated timelines.
3. Submit a written complaint online. Log in at express-scripts.com and use the message center or contact form. Written submissions create a time-stamped formal record.
4. Send a certified letter to HQ at Express Scripts, Inc., Attn: Patient Relations, 1 Express Way, St. Louis, MO 63121. Include your member ID, prescription details, prior case numbers, and the resolution requested.
5. File with your State Insurance Commissioner. State-level regulators increasingly have direct PBM oversight authority for coverage decisions, billing, and network practices.
6. File with CMS for Medicare Part D complaints at medicare.gov or by calling 1-800-MEDICARE (1-800-633-4227). CMS has direct regulatory authority over Medicare PBM operations.
7. File with the BBB at bbb.org for a formal public record requiring a company response.
8. File with the FTC at reportfraud.ftc.gov — the FTC has increased PBM oversight and handles deceptive billing and unfair practice complaints.